An ultrasound-guided percutaneous kidney biopsy is a minimally invasive procedure used to obtain small samples of kidney tissue for diagnosis. Guided by real-time ultrasound imaging, a thin needle is inserted through the skin into the kidney to collect tissue. This helps doctors evaluate kidney disease, monitor transplant health, or guide treatment decisions. The procedure is usually performed under local anesthesia, with patients observed afterward to ensure safety. Most can return to normal activities within a short period, following medical advice.